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Cell biology by the numbers
- The Path to Biological Numeracy
- I: Size and Geometry
- II: Concentrations and Absolute Numbers
- Making a cell
- Concentrations and Absolute Numbers – Introduction
- What is the elemental composition of a cell?
- What is the density of cells?
- What are environmental O2 and CO2 concentrations?
- What quantities of nutrients need to be supplied in growth media?
- What is the concentration of bacterial cells in a saturated culture?
- Cell census
- What is the pH of a cell?
- What are the concentrations of different ions in cells?
- What are the concentrations of free metabolites in cells?
- What lipids are most abundant in membranes?
- How many proteins are in a cell?
- What are the most abundant proteins in a cell?
- How much cell-to-cell variability exists in protein expression?
- What are the concentrations of cytoskeletal molecules?
- How many mRNAs are in a cell?
- What is the protein to mRNA ratio?
- What is the macromolecular composition of the cell?
- Machines and signals
- Making a cell
- III: Energies and Forces
- Biology meets physics
- Energies and Forces – Introduction
- What is the thermal energy scale and how is it relevant to biology?
- What is the energy of a hydrogen bond?
- What is the energy scale associated with the hydrophobic effect?
- How much energy is carried by photons used in photosynthesis?
- What is the entropy cost when two molecules form a complex?
- How much force is applied by cytoskeletal filaments?
- What are the physical limits for detection by cells?
- Energy currencies and budgets
- How much energy is released in ATP hydrolysis?
- What is the energy in transfer of a phosphate group?
- What is the free energy released upon combustion of sugar?
- What is the redox potential of a cell?
- What is the electric potential difference across membranes?
- What is the power consumption of a cell?
- How does metabolic rate scale with size?
- Biology meets physics
- IV: Rates and Duration
- Time scales for small molecules
- Rates and Durations – Introduction
- What are the time scales for diffusion in cells?
- How many reactions do enzymes carry out each second?
- How does temperature affect rates and affinities?
- What are the rates of membrane transporters?
- How many ions pass through an ion channel per second?
- What is the turnover time of metabolites?
- Central dogma
- Cellular dynamics
- Cell life cycle
- Time scales for small molecules
- V: Information & Errors
- VI: A Quantitative Miscellany
- A Quantitative Miscellany – Introduction
- How many cells are there in an organism?
- How many chromosome replications occur per generation?
- How many ribosomal RNA gene copies are in the genome?
- What is the permeability of the cell membrane?
- How many photons does it take to make a cyanobacterium?
- How many virions result from a single viral infection?
- Epilogue
